Amelia (ATLAS Multimedia Educational Lab for Interactive Analysis) is a project for High-Energy physics featuring the ATLAS detector at
CERN, the world's largest particle physics lab. The application looks like this:
Using the
Irrlicht engine and
irrKlang, AMELIA integrates event analysis and contextual media in a 3D interface. The project is open source and IMO one of the more impressive (maybe also because I have don't know anything about those physics ;)) non-game projects made with these libraries.